Usage test – Required D-Value (RDV)
| Regulatory reference: | Proprietary method |
| Claim: | Efficacy of preservatives |
| Application field: | Cosmetic products. |
| Description of the test: | In vitro and in vivo evaluation RDV for the determination of the PAO (Period After Opening). |
Evaluation of the microbial contamination risk and water activity
| Regulatory reference: | ISO 29621 |
| Claim: | Free water percentage calculation and Low microbial contamination risk |
| Application field: | Cosmetics. |
| Description of the test: | Evaluation of the risk of microbial contamination in a cosmetic product by ISO 29621 method for the determination of water activity (Aw) parameter. |
Antimicrobial activity test vs Propionibacterium acnes
| Regulatory reference: | Proprietary method |
| Claim: | Anti-acne |
| Application field: | Cosmetics and raw cosmetic ingredients. |
| Description of the test: | Evaluation of the anti-acne efficacy by testing the inhibition of the proliferation of Propionibacterium acnes by an ingredient or finished product. |
Posted in Acne, Anti-acne, Cosmetic raw materials
Antioxidant efficacy test: ORAC Test
| Regulatory reference: | UE Regulations |
| Claim: | Antioxidant |
| Application field: | Active ingredients for cosmetics products and medical devices. |
| Description of the test: | Quantification of the antioxidant efficacy through ORAC (Oxygen Radical Absorbance Capacity) test. |
Posted in Anti age, Antioxidant, Claim for cosmetics
Quantification of trace substances and impurities
| Regulatory reference: | UE Regulation |
| Claim: | Titer of substances |
| Application field: | Cosmetics and medical devices. |
| Description of the test: | Analysis of trace substances, residues and impurities for quality control purposes through UPLC or GC-MS. Includes sample preparation. |
Quantification of the titer of substances
| Regulatory reference: | Regulation 1223/209 |
| Claim: | Titer of substances and Limit of preservatives |
| Application field: | Preservatives, dyes, sunscreen filters. |
| Description of the test: | Quantification method for the measurement of the titer of substances by HPLC, UPLC, GC-MS after preparative steps. |
Stability test
Posted in Filter devices, shielding films and plasters, Heating and cooling products, Mucoadhesive products, Protection and barrier effect, Accelerated stability test, Substance-based, Surgical devices and medications, Make up, Claim for cosmetics, Claim for medical devices, Accelerated stability tests
Hair loss prevention efficacy test
| Regulatory reference: | Guidelines to Commission Regulation (EU) No 655/2013 |
| Claim: | Hair loss protection |
| Application field: | Cosmetic products for hair and scalp treatment. |
| Description of the test: | Clinical objective evaluation with high resolution imaging. Pull test: count of the number of hairs collected under standardized traction. Trichographic analysis through cell biology techniques, and evaluation of the biological activity of collected hairs from each volunteer through MTT evaluation of cell vitality.
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Posted in Hair loss protection, Hair products, Claim for cosmetics
Lenitive and anti-itching efficacy test during acute phases of induced irritation
| Regulatory reference: | Guidelines to Commission Regulation (EU) No 655/2013 |
| Claim: | Lenitive effect and Itch soothing |
| Application field: | Visage and body cosmetics. |
| Description of the test: | Instrumental measurements with Minolta CR200 colorimeter performed to determine the phototype of the predefined skin region and the correlated MEDu. The hemoglobin content of the target area is measured using a Courage MX18 Mexameter®-Khazaka GmbH. Lenitive, soothing and anti-itching efficacy is measured against histamine, UV or chemically induced irritation. |
Posted in Itch soothing, Lenitive effect, Lenitive products, Claim for cosmetics
Evaluation of depigmenting efficacy
| Regulatory reference: | Guidelines to Commission Regulation (EU) No 655/2013 |
| Claim: | Reduces skin blemishes, Skin whitening and Depigmenting action |
| Application field: | Visage and body cosmetic products. |
| Description of the test: | Instrumental measurements performed using a Minolta CR200 colorimeter will be performed at T=0 and T=X days (to be defined by previous agreement with the sponsor) in order to evaluate changes in the pigmentation of the treated area. The measurements will be performed at each time point in the same area. Acquisition of high definition images will be performed at T=0 and T=X days using a macro objective with color normalization and coaxial circular flash. |
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