Seboregulation activity test and count of closed and open comedones
| Regulatory reference: | Guidelines to Commission Regulation (EU) No 655/2013 |
| Claim: | Non-comedogenic and Seboregulating |
| Application field: | Visage and body cosmetics for oily skin. |
| Description of the test: | Sebometric measurements in triplicate performed with Sebometer® at T=0 and T=X days after the treatment. Measurements will be performed on the cheeks after treatment. The untreated forehead will be used as a control. The measurements will compensate for circadian rhythms and will therefore be performed at the same time during the day. Open and closed comedones will be counted under Wood’s lamp illumination. Clinical evaluation of high resolution imaging will be performed using a contrast system at T=0 and after X days of treatment. |
Posted in Acne, Seboregulating, Non-comedogenic, Claim for cosmetics
Antimicrobial activity test vs Propionibacterium acnes
| Regulatory reference: | Proprietary method |
| Claim: | Anti-acne |
| Application field: | Cosmetics and raw cosmetic ingredients. |
| Description of the test: | Evaluation of the anti-acne efficacy by testing the inhibition of the proliferation of Propionibacterium acnes by an ingredient or finished product. |
Posted in Acne, Anti-acne, Cosmetic raw materials
5α-reductase inhibition efficacy test by mRNA analysis on dermal papillae cells
| Regulatory reference: | Proprietary method |
| Claim: | Seboregulating |
| Application field: | Active ingredients or finished products. |
| Description of the test: | Quantification of the changes in the gene expression of 5α-reductase in human dermal papilla cells. Demonstration of the efficacy of the ingredient or finished product in reducing the expression of mRNA codifying for 5α-reductase type I or II. |
Posted in Acne, Seboregulating, Claim for cosmetics
5α-reductase inhibition efficacy test by mRNA analysis
| Regulatory reference: | Proprietary method |
| Claim: | Seboregulating and Hair loss protection |
| Application field: | Active ingredients or finished products. |
| Description of the test: | Quantification of the changes in the gene expression of 5α-reductase in murine Balb/3T3 fibroblasts. Demonstration of the efficacy of the ingredient or finished product in reducing the expression of mRNA codifying for 5α-reductase type I or II. |
Posted in Acne, Seboregulating, Hair loss protection, Hair products, Claim for cosmetics
5α-reductase inhibition efficacy test
| Regulatory reference: | Proprietary method |
| Claim: | Seboregulating and Hair loss protection |
| Application field: | Active ingredients or finished products. |
| Description of the test: | Analysis of the in vitro expression of the 5α-reductase enzyme by real time PCR in comparison with untreated substrates for the evaluation of inhibition effects. Demonstration of the efficacy of the ingredient or finished product in reducing the expression of mRNA codifying for 5α-reductase type I or II. |
Posted in Acne, Seboregulating, Hair loss protection, Hair products, Claim for cosmetics
Lipase stimulation efficacy test
| Regulatory reference: | Proprietary method |
| Claim: | Anti-cellulite and Seboregulating |
| Application field: | Active ingredients or finished products. |
| Description of the test: | Analysis of the activation of the activity of enzymatic lipase in a controlled triglyceride hydrolysis reaction. |
Posted in Acne, Anti-cellulite, Seboregulating, Cellulite, Claim for cosmetics
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