Highlights
Contacts
| Email: | info.abich@lifeanalytics.it |
| Phone: | +39 0323 586239/496041 |
| Address: | Via Quarantadue Martiri, 213/B - 28924 Verbania (VB) Italy |
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| Regulatory reference: | OECD 442D |
| Claim: | No skin sensitizing and Hypoallergenic |
| Application field: | Substances or mixtures. |
| Description of the test: | The ARE-Nrf2 method employs cytofluorometry to quantify the antioxidant response in a culture of human keratinocytes after exposure to the product. |
| Regulatory reference: | OECD 442E |
| Claim: | No skin sensitizing and Hypoallergenic |
| Application field: | Substances or mixtures. |
| Description of the test: | H-CLAT cytometry method to evaluate possible changes in the expression of cell surface markers (CD86 e CD54) in cultures of THP-1 human monocytes to exclude the related sensitization pathway. |
| Regulatory reference: | OECD 442C |
| Claim: | No skin sensitizing and Hypoallergenic |
| Application field: | Substances or mixtures without metal compounds. |
| Description of the test: | The DPRA is proposed to address the molecular initiating event of the skin sensitisation AOP (Adverse Outcome Pathway), namely protein reactivity, by quantifying the reactivity of test chemicals towards model synthetic peptides containing either lysine or cysteine. Cysteine and Lysine percent peptide depletion values are then used to categorise a substance in one of four classes of reactivity for supporting the discrimination between skin sensitisers and non-sensitisers. |
| Email: | info.abich@lifeanalytics.it |
| Phone: | +39 0323 586239/496041 |
| Address: | Via Quarantadue Martiri, 213/B - 28924 Verbania (VB) Italy |
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